丁其勇 滑炎卿 管一暉 趙軍 朱鳳 毛定飚 葛虓俊 張國(guó)楨
【摘要】 目的 探討非小細(xì)胞肺癌動(dòng)態(tài)CT 增強(qiáng)值與正電子發(fā)射計(jì)算機(jī)體層攝影( PET) 中
18 氟-脫氧葡萄糖( 18F-FDG) 標(biāo)準(zhǔn)攝取值( SUV) 的相關(guān)性。方法 搜集行PET-CT 和動(dòng)態(tài)增強(qiáng)CT 檢查
的28 例非小細(xì)胞肺癌和13 例良性肺結(jié)節(jié)病例, 測(cè)量結(jié)節(jié)增強(qiáng)前后各時(shí)相的平均CT 值、18 F-FDG 標(biāo)
準(zhǔn)攝取值的最大值和平均值, 計(jì)算結(jié)節(jié)增強(qiáng)峰值, 用Pea rson 相關(guān)分析方法評(píng)價(jià)良惡性結(jié)節(jié)動(dòng)態(tài)CT
增強(qiáng)峰值和18 F-FDG SUV 的相關(guān)性。結(jié)果 非小細(xì)胞肺癌和良性結(jié)節(jié)CT 增強(qiáng)峰值[ ( 35. 09 ±
11. 41) 、( 26. 92 ±19. 98) HU] 的差異無(wú)統(tǒng)計(jì)學(xué)意義( t = 1. 374, P = 0. 189) , SUV 最大值( 7. 23 ±4. 38、
2. 97 ±2. 80) 差異有統(tǒng)計(jì)學(xué)意義( t = - 3. 972, P < 0. 001 ) , SUV 平均值差異有統(tǒng)計(jì)學(xué)意義( t =
- 4. 061, P < 0. 001) 。非小細(xì)胞肺癌CT 增強(qiáng)峰值[ ( 35. 09 ±11. 41) HU] 和18 F-FDG SUV 的平均值
( 4. 93 ±3. 53) 及最大值( 7. 23 ±4. 38) 之間均無(wú)相關(guān)關(guān)系( r = - 0. 040, P = 0. 839 及r = 0. 056, P =
0. 778) 。結(jié)論 非小細(xì)胞肺癌動(dòng)態(tài)CT 增強(qiáng)值與FDG SUV 之間無(wú)相關(guān)關(guān)系, FDG SUV 可能不適用于
非小細(xì)胞肺癌抗腫瘤血管生成治療的療效評(píng)價(jià)。
【關(guān)鍵詞】 肺腫瘤; 體層攝影術(shù),X 線計(jì)算機(jī); 體層攝影術(shù), 發(fā)射型計(jì)算機(jī); 氟脫氧葡萄糖F18
Corr elative investigation of dynamic contr ast CT a nd positr on emission tomogr aphy with
18-fluor odeoxy glucose standar dized uptake value in non -small cell lung cancer DING Qi-yong* ,
HUA Ya n-qing, GUAN Yi-hui, ZHAO Jun, ZHU Feng, MAO Ding-biao, GE Xia o-jun, ZHANG Guo-zhen.
* Department of Ra diology, Hua dong Hospital, Shanghai 200040, China
【Abstra ct 】 Object ive To explore the correlation of dynamic enhanced CT attenuation and
18-fluorodeoxy glucose ( 18 F-FDG ) standardized uptake value ( SUV) in non-small cell lung cancer
( NSCLC) . Met hods Twenty-eight NSCLC patients and 13 patients with benign nodules ( 28 male,
13 female; age range 15 - 79 years, median 57 years; the diameter range from 0. 8 - 4. 0 cm, mean
2. 2 cm) were examined on Siemens biograph sensation 16 PET-CT with 18F-FDG. Dynamic enhanced CT
scan was performed on Siemens sensation 16 PET-CT or 16 slice CT in 23 patients and other 18 patients had
the results of dynamic CT from other hospitals. The mean CT attenuation of ROI on precontrast and
postcontrast multi-phase images , the maxium and average SUV of 18 F-FDG were respectively measured. The
correlation between the peak attenuation( APA) and SUV was analyzed with pearson correlation coefficient
test. Result s The CT APA between NSCLC and benign nodules had no significance difference ( t = 1. 374,
P = 0. 189) . The difference of maximum and average SUV between NSCLC and benignity were significant
( t = - 3. 972, P < 0. 001 & t = - 4. 061, P < 0. 001 respectively) . No correlation was found among APA,
maximum SUV ( 7. 23 ±4. 38) , and average SUV( 4. 93 ±3. 53) ( r = - 0. 040, P = 0. 839 & r = 0. 056,
P = 0. 778) . Conclusion There is no correlation between APA and SUV in NSCLC. SUV is probably not
suitable for the evaluation of the effects of anti-angiogenesis therapy.
【Key words 】 Lung neoplasms; Tomography, X-ray computed; Tomography, emissioncomputed;
Fludeoxyglucose F18

非小細(xì)胞肺癌動(dòng)態(tài)CT 增強(qiáng)值與正電子.rar