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  首頁 > 美迪醫訊 > 嬰兒:新的試驗能幫助防止傳染  

嬰兒:新的試驗能幫助防止傳染

【?2008-10-08 發布?】 美迪醫訊
美迪網領先的醫療器械電子商務平臺


一個新的診斷記錄可以幫助確定嬰兒是否受到高風險的細菌傳染并且潛在的減少了不必要的測試、藥物治療或是去低風險的嬰兒的組員治療。
一個簡單的血液測試也許可以幫助因不明原因發燒來到急診室嬰兒發現嚴重細菌傳染,如尿道感染和血液感染,研究者利用一個新的降血鈣素計分測試,最近在美國食品藥品管理局得到認可。在234例出生不到三個月出現發燒癥狀的嬰兒中18%有嚴重的細菌感染,這在一些相互獨立的診所中被證實。
這個結果表明降血鈣素不只用于識別所有嚴重細菌感染引起發燒的嬰兒,而且被證實足夠敏感去用來識別嬰兒低風險的細菌感染。事實上,它所表現的就像當前一個單獨的診所關于確認是否感染的包括多種試驗室測試和醫療診所評估的一整套策略。
因為醫療人員不能準確地確定哪些發燒的兒童有更嚴重的感染。很多嬰兒最后經歷了廣泛的測試。對小于3個月的于嬰兒常規的評估包括血液檢查,尿樣分析并且常常要進行腰椎穿刺,之后要在醫院進行抗生素治療。對于目前相對低效率的對嬰兒發燒癥狀的治療,研究者找到了一個快速確認第一次來急診室檢查的兒童是否有細菌感染的診斷方法。
這項降血鈣素測試高靈敏性允許科學家去建立準確的評估以幫助指導臨床醫生去識別哪些兒童是低風險的細菌感染者。研究者目前正試圖通過多種研究來找到降血鈣素更廣泛的用途。

 

Babies: New Test Can Help Catch Infections
A new diagnostic marker can help identify infants at high risk for serious bacterial infections and potentially reduce unneeded testing, medication or hospitalisation in low risk infants. 07/10/2008
A simple blood test may help detect serious bacterial infections (SBIs) like urinary tract infections and blood stream infections in young infants who come to the emergency department (ED) with fevers that have no clear cause. The researchers used a novel test with the marker procalcitonin, recently approved by the U.S. Food and Drug Administration (FDA), in 234 feverish babies under three months of age, of whom 18 percent had definite or possible SBIs confirmed by independent clinical criteria.

The results showed that procalcitonin not only detected all cases of SBIs in feverous infants but proved sensitive enough to establish a threshold value that would identify infants at low risk for serious infections. Indeed, its overall performance as a single clinical marker of infection approached that of current strategies that involve a variety of laboratory tests and clinical evaluations.

Because clinicians cannot reliably determine which children with fever have more serious infections, many babies end up undergoing extensive evaluations. Routine evaluation of infants less than three months of age includes blood tests, urine tests, and often a lumbar puncture for spinal fluid, followed by treatment in the hospital with antibiotics. Prompted by the inefficiency of current fever management in young infants, the researchers have sought a rapid diagnostic test that will determine which children have serious infections at the first visit to the ED.

The high sensitivity of the new procalcitonin test has allowed the scientists to establish realistic cut-off values to help guide clinicians in identifying children who are at low risk for SBIs. The researchers are now looking to do a multi-center study to evaluate the use of procalcitonin on a larger scale.
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