一種敏感的血液學(xué)檢測(cè)用于折疊蛋白疾病，例如牛海綿體腦病，又叫做瘋牛病，能夠提供早期診斷。

這種檢測(cè)使用小型的、模擬蛋白折疊的合成肽類(lèi)。這些肽類(lèi)檢測(cè)方法能夠在有害蛋白質(zhì)在大腦蓄積之前，檢測(cè)出血液中的蛋白。這些有害蛋白質(zhì)的蓄積與大腦損傷、疾病癥狀盒最終的死亡有關(guān)聯(lián)。

這種檢測(cè)方法是由Cindy Orser醫(yī)生研制的，他是Adlyfe公司的研究與開(kāi)發(fā)副總裁。這種檢測(cè)方法設(shè)計(jì)用于檢測(cè)綿羊瘋癢病和人類(lèi)Cruetzfeld-Jacob病也就是瘋牛病。該公司對(duì)該項(xiàng)技術(shù)擁有11項(xiàng)，該技術(shù)同樣可以用于其他蛋白折疊疾病例如Alzheimer病和Huntington病。Adlyfe公司已經(jīng)在牛、綿羊和人類(lèi)的臨床實(shí)驗(yàn)室采集的大腦組織和血液樣本中檢測(cè)出了蛋白感染素疾病。

Adlyfe公司首席執(zhí)行官Alan S. Rudolph評(píng)論說(shuō)：“我們對(duì)測(cè)試的早期結(jié)果感到十分鼓舞，這標(biāo)志著我們能夠從動(dòng)物和人類(lèi)的血液和組織樣本中成功檢測(cè)出疾病。我們希望能夠?yàn)檫@些惡性疾病的早期檢測(cè)和診斷提供新的檢測(cè)方法。”Adlyfe是一家生物科技公司，側(cè)重于新型血液診斷和治療領(lǐng)域。

Blood Test for Mad Cow Disease
 
A sensitive blood test for protein-folding diseases such as spongiform bovine encephalopathy (SBE), also known as mad cow disease, could provide an earlier diagnosis.

The test uses small, synthetic peptides that mimic protein folding. The peptides detect the build-up of damaging proteins in blood before they accumulate in the brain. This accumulation is correlated to brain damage, disease symptoms, and eventual death.

The test was developed by Dr. Cindy Orser, vice president, research and development, Adlyfe, Inc. (Rockville, MD, USA). The test is designed to detect sheep scrapie and Cruetzfeld-Jacob disease in humans as well as mad cow disease. The company has 11 patents pending on the technology, which also addresses other protein-folding diseases such as Alzheimer’s and Huntington’s disease. Adlyfe has demonstrated detection of prion diseases in brain tissue and the blood of cattle, sheep, and humans in clinical laboratory sampling.

“We are very encouraged by the early results of our test which show we can detect disease in blood and tissue samples from animals and humans,” commented Alan S. Rudolph, CEO of Adlyfe. “We look forward to offering a new test for early detection and diagnosis of these debilitating diseases.” Adlyfe is a biotechnology company focused on novel blood diagnostics and therapeutics.