一項研究發(fā)現(xiàn)，遺傳因素在體重的調(diào)節(jié)和維持中發(fā)揮作用，還可能在確定患者對腹腔鏡調(diào)節(jié)胃部粘合手術(shù)(LAGB)的反應(yīng)。

迄今為止，醫(yī)生還不知道影響患者對LAGB治療反應(yīng)的基因因素，該治療是一種治療肥胖癥的外科手術(shù)，用于限制胃上部的膨脹容積，從而制造一種較小的胃袋，限制進食并產(chǎn)生飽腹感。

研究人員評估了近期接受LAGB治療的167例肥胖患者的成功之處。每例患者都接受特定基因變異、或者單個核苷的多態(tài)性，從而確定接受這種外科手術(shù)治療患者體重減輕的因素。在隨訪6個月之后，G-174G IL6基因型受試者比G-174C或者C-174G基因型受試者體重下降的更多，A-866A UCP2基因型比G-866G或者G-866A基因型體重下降更多。這些結(jié)果顯示，遺傳因素確實影響體重的調(diào)節(jié)和維持。

來自意大利Catanzaro的Magna-Graecia大學(xué)臨床與實驗醫(yī)學(xué)系的研究人員認(rèn)為，基因或許在影響患者對LAGB治療反應(yīng)中發(fā)揮作用。在2005年9月《臨床內(nèi)分泌與代謝期刊》上報道他們的研究結(jié)果。
 
Genetic Impact on Gastro Surgery
 
A study has found that genetics play a role in the regulation and maintenance of body weight and may also help determine a patient’s response to laparoscopic adjustable gastric binding (LAGB).

Until now, doctors have not known whether genetic factors affected a patient’s response to LAGB, a type of surgery for obesity that entails placing an inflatable band around the upper stomach to create a small gastric pouch that limits food consumption and creates a feeling of fullness.

Researchers evaluated the success of 167 morbidly obese patients who had recently undergone LAGB. Each was evaluated for specific genetic variants, or single nucleotide polymorphisms, to see how each affected weight loss following this type of surgery. After six months of follow-up, subjects with a G-174G IL6 genotype lost more weight than subjects with a G-174C or C-174G genotype, while subjects with an A-866A UCP2 genotype lost more weight than subjects with a G-866G or G-866A genotype. The findings show that genetics do influence the regulation and maintenance of body weight.

The researchers, from the department of clinical and experimental medicine, University of Magna-Graecia in Catanzaro (Italy), suggest that genes may also play a role in the success of a subject’s response to LAGB. Their findings were reported in the September 2005 issue of The Journal of Clinical Endocrinology & Metabolism.