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首頁(yè) > 美迪醫(yī)訊 > BioMosaics生產(chǎn)出檢測(cè)肝癌的單克隆抗體 |
BioMosaics生產(chǎn)出檢測(cè)肝癌的單克隆抗體 【?2006-07-31 發(fā)布?】 美迪醫(yī)訊
GPC3屬于糖基磷脂酰肌醇-錨定細(xì)胞表面硫酸乙酰肝素蛋白多糖家族。1G12單克隆抗體已經(jīng)被用于惡性和非惡性肝臟組織中檢測(cè)GPC3表達(dá),以及檢測(cè)血清中ELISA檢測(cè)GPC3。通過(guò)免疫組化檢測(cè)發(fā)現(xiàn)在蛋白水平,大多數(shù)原發(fā)性肝癌表達(dá)GPC3,包括小肝癌,但是在正常肝臟和良性肝臟病變檢測(cè)不出。在大部分原發(fā)性肝癌患者血清中GPC3水平顯著升高。這種單克隆抗體是BioMosaics公司(Burlington, VT, USA)的產(chǎn)品。 GPC3 is a member of the glypican family of glycosyl phosphatidylinositol-anchored cell-surface heparan sulfate proteoglycans. The 1G12 monoclonal antibody has been used to assess GPC3 expression in malignant and non-malignant liver tissue samples and for enzyme-linked immunosorbant assay (ELISA) detection of GPC3 in the serum. GPC3 is expressed at the protein level by immunohistochemistry in most cases of primary liver cancer including small tumors, but is undetectable in normal liver and benign hepatic lesions. GPC3 is significantly elevated in the serum of a large proportion of patients with primary liver cancer. The monoclonal antibody product was developed by BioMosaics (Burlington, VT, USA). 本文關(guān)鍵字:
BioMosaics
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