根據一項最新研究發現，核心針孔穿刺診斷乳腺癌的基因表達譜檢測，是腫瘤基因表達檢測的一個代表，是乳腺癌診斷的一個可靠指標。

這項研究發表在2006年8月的《乳腺癌研究期刊》之上，驗證了核心針孔穿刺活檢作為乳腺癌診斷和預后手段的可靠性。該研究還顯示核心針孔穿刺診斷乳腺癌，可能比穿刺之后從腫瘤上手術獲取標本的精確性要高。根據這些研究結果，活檢手術觸發了與損傷修復相關的基因表達，從而改變了后續手術采集樣本的基因表達譜。

 
Gene Expression in Core Needle Biopsy Diagnoses Breast Cancer
 
The gene-expression profile detected in a core needle biopsy of a breast tumor is representative of gene expression in the whole tumor and therefore a reliable diagnostic for breast cancer, according to a new study.

The study, published in the August 2006 edition of the journal Breast Cancer Research, confirms the reliability of core needle biopsy as a tool in breast-cancer diagnosis and prognosis. The study also shows that the gene expression profile of a core needle biopsy might be more accurate than the profile of a surgical sample taken from the same tumor after the biopsy was carried out. According to the study results, the biopsy procedure triggers the expression of genes involved in wound healing as well as tumor invasion and metastasis, thus modifying the gene expression profile of subsequent surgical samples.