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首頁 > 美迪醫訊 > 純氧可對大腦造成損傷 |
純氧可對大腦造成損傷 【?2007-06-08 發布?】 美迪醫訊
最新的研究表明吸入純氧實際上能損傷大腦,在純氧中摻入二氧化碳可以保護病人的大腦。 美國加利福尼亞大學的研究學者使用MRI獲取詳細的圖像資料,關于兩個不同呼吸組大腦中發生的變化。研究學者掃描了14個健康兒童的大腦,這些兒童的年齡在8到15歲,并且監測當他們通過特殊裝置吸入100%純氧2分鐘后呼吸和心率的變化。8分鐘后直到最小的兒童呼吸恢復到正常,一組研究對象在所呼吸的氧氣中添加5%的二氧化碳,并重復剛才的掃描工作。對照組和研究組的比較表明兩者間存在顯著的差別。 第一作者神經生物學專家Ronald Harper解釋說,大腦中的很多部分都會對100%純氧做出反應,并且最終刺激下丘腦。下丘腦當血液中出現大量激素和神經轉運體時會過度反應。這些化學物質可干擾心臟泵血的穩定性,而純氧在復蘇病人的同時可能產生相反的效應。 然而,當研究對象吸入含有二氧化碳混合氣體后,通過MRI監測發現下丘腦的高反應性消失。研究學者得出結論,純氧中的二氧化碳能擴張血管,使氧氣能到達心臟和大腦,使下丘腦恢復刺激前的狀態并且減慢危險性化學物質的釋放速率。這項研究出版于PLoS醫學版雜志2007年5月號。 基于他們的發現,大大促進健康醫療部門在純氧中添加二氧化碳成分,尤其是在嬰兒復蘇以及吸入純氧一段時間后。這種指導性治療方法可運用于休克、心臟損傷、一氧化碳中毒以及長時氧氣等方面的治療。 來源:medinews.com Pure Oxygen Can Damage the Brain New research suggests that inhaling pure oxygen can actually harm the brain, and recommends adding carbon dioxide to the mix to preserve brain function in patients. Researchers at the University of California, Los Angeles (UCLA; USA) used functional magnetic resonance imaging (fMRI) to capture detailed imagesof what occurs inside the human brain during two different breathing scenarios. The researchers scanned the brains of 14 healthy children, ages 8 to 15, and monitored their breathing and heart rates as they inhaled 100% oxygen through a mouthpiece for two minutes. After waiting eight minutes for the youngsters’ breathing to return to normal, the team added 5% carbon dioxide to the gas mixture and repeated the scan. A comparison of the two scans revealed dramatic differences. everal brain areas responded to 100% oxygen by kicking the hypothalamus into overdrive,?explained lead author Ronald Harper, a professor of neurobiology at the David Geffen School of Medicine at UCLA. 揟he hypothalamus overreacted by dumping a massive flood of hormones and neurotransmitters into the bloodstream. These chemicals interfere with the heart’s ability to pump blood and deliver oxygen--the opposite effect you want when you’re trying to resuscitate someone.? However, when the children inhaled the carbon dioxide-oxygen mix, the hypothalamus’ hyperactivity vanished from the MRI scan. The researchers concluded that adding carbon dioxide to the oxygen relaxed the blood vessels, allowed oxygen to reach the heart and brain, calmed the hypothalamus, and slowed the release of the dangerous chemicals. The study was published in the May 22, 2007, edition of the journal Public Library of Science (PLoS) Medicine. Based on their findings, the researchers strongly encourage health care providers to add carbon dioxide to oxygen dispensation, especially when resuscitating infants or administering oxygen for more than a few minutes. The new direction could hold particular implications for patients of stroke, heart attack, carbon monoxide poisoning, and any long-term oxygen therapy. Related Links: University of California, Los Angeles 《美迪醫訊》歡迎您參與新聞投稿,業務咨詢: 美迪醫療網業務咨詢
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