對(duì)兩項(xiàng)減肥手術(shù)中使用的技術(shù)的研究顯示：與胃改道術(shù)相比較，billopancreatic轉(zhuǎn)移能夠?qū)⒒颊咭葝u素敏感性增加1倍。

超重患者面臨學(xué)多醫(yī)學(xué)問(wèn)題，包括胰島素抵抗以及2型糖尿病。對(duì)這些患者進(jìn)行減肥手術(shù)使得體重下降，而胰島素敏感性增加。在研究中，體重嚴(yán)重超標(biāo)的18例非糖尿病患者與20例對(duì)照患者進(jìn)行了代謝功能檢測(cè)，包括測(cè)定胰島素活性。肥胖患者接受胃改道手術(shù)（通過(guò)較小胃體積來(lái)限制食物攝入），或者Billopancreatic轉(zhuǎn)移（縮短小腸減少脂肪吸收）。患者術(shù)后5～6月以及16～24月接受隨訪。

巴西Campinas州立大學(xué)(Sao Paulo, Brazil)Alza Muscelli醫(yī)生解釋說(shuō)：“在當(dāng)前的研究中，胃改道手術(shù)與Billopancreatic轉(zhuǎn)移手術(shù)的生理學(xué)差異得到了探討，突出了脂質(zhì)吸收障礙與胰島素活性支架的關(guān)系。但是，這些患者選擇最佳治療方案是根據(jù)風(fēng)險(xiǎn)/效益法則進(jìn)行評(píng)估的。”

這項(xiàng)研究發(fā)表在2005年1月《美國(guó)醫(yī)學(xué)期刊》 上。其它研究人員來(lái)自羅馬Catholic大學(xué)以及Pisa大學(xué)。
 
Bariatric Technique Increases Insulin Sensitivity
 
A study of two techniques used in weight-loss surgery shows that billopancreatic diversion can double insulin sensitivity in patients, compared to gastric bypass surgery.

Excessively overweight patients can have many medical problems, including insulin resistance and often type 2 diabetes. Bariatric surgery for such patients leads to weight loss and improves insulin sensitivity. In the study, 18 nondiabetic patients with severe obesity and 20 lean subjects underwent metabolic studies, including the measurement of insulin activity. The obese patients then underwent either gastric bypass, which restricts food intake by making the stomach very small, or billopancreatic diversion, which shortens the small intestine and reduces fat absorption. Patients were followed at five to six months and again at 16-24 months after surgery.

“In the present study, the physiological difference between gastric bypass and billopancreatic diversion was exploited to highlight the link between lipid malabsorption and insulin action,” explained Alza Muscelli, M.D., of the State University of Campinas (Sao Paulo, Brazil). “However, the choice of the optimal therapeutic strategy in these patients depends on a risk/benefit algorithm to be assessed in each patient.”

The study was published in the January 2005 issue of The American Journal of Medicine. Other researchers from the Catholic University in Rome (Italy) and the University of Pisa (Italy) also participated in the study.